Role of magnetic resonance imaging before initial biopsy: comparison of magnetic resonance imaging-targeted and systematic biopsy for significant prostate cancer detection
Top Cited Papers
- 22 March 2011
- journal article
- research article
- Published by Wiley in BJU International
- Vol. 108 (8b), E171-E178
- https://doi.org/10.1111/j.1464-410x.2011.10112.x
Abstract
•To compare magnetic resonance imaging (MRI)-targeted biopsies with extended systematic biopsies for the detection of significant prostate cancer. •In all, 555 consecutive patients with suspicion of prostate cancer had pre-biopsy dynamic contrast-enhanced 1.5-tesla (T) MRI with pelvic coil, 10-12 transrectal ultrasound-guided extended systematic biopsies plus two targeted biopsies at any MRI area suspicious for malignancy. •Significant prostate cancer was defined as >5 mm total cancer length and/or any Gleason pattern >3. •Cancer length and grade at biopsy were reported and located on a 24-sector map. •Median (range) prostate-specific antigen (PSA) was 6.75 (0.18-100) ng/mL. •MRI was positive in 351 (63%) patients and, overall, 302 (54%) had cancer at extended systematic biopsies and/or targeted biopsies. Of 302 cancers detected, 249 (82%) were significant prostate cancers and 53 (18%) were nonsignificant prostate cancers. •Extended systematic biopsies did not detect 12 significant prostate cancers and targeted biopsies did not detect 13 significant prostate cancers. For significant prostate cancer detection, sensitivity, specificity and accuracy of targeted biopsies were 0.95, 1.0 and 0.98. The values for extended systematic biopsies were 0.95, 0.83, and 0.88. •The detection accuracy of significant prostate cancer by targeted biopsies was higher than that by extended systematic biopsies (P < 0.001). Targeted biopsies also detected 16% more grade 4/5 cases and better quantified the cancer than extended systematic biopsies, with cancer length of 5.56 vs. 4.70 mm (P= 0.002). • A targeted biopsies-only strategy without extended systematic biopsies would have necessitated a mean of 3.8 cores performed in only 63% of patients with positive MRI and avoided the potentially unnecessary diagnosis of 13% (53/302) of nonsignificant prostate cancers. • Strategy of targeted biopsies alone at pre-biopsy MRI-suspicious areas is an attractive potential alternative to extended systematic biopsies for detection of significant prostate cancer. •Further studies are necessary to validate the strategy of targeted biopsies alone.Keywords
This publication has 29 references indexed in Scilit:
- Is it time to consider a role for MRI before prostate biopsy?Nature Reviews Clinical Oncology, 2009
- Thirty-Two-Channel Coil 3T Magnetic Resonance-Guided Biopsies of Prostate Tumor Suspicious Regions Identified on Multimodality 3T Magnetic Resonance Imaging: Technique and FeasibilityInvestigative Radiology, 2008
- Saturation Technique Does Not Decrease Cancer Detection During Followup After Initial Prostate BiopsyJournal of Urology, 2008
- Initial clinical experience with real‐time transrectal ultrasonography‐magnetic resonance imaging fusion‐guided prostate biopsyBJU International, 2008
- How Good is MRI at Detecting and Characterising Cancer within the Prostate?European Urology, 2006
- MRI-Guided Biopsy of the Prostate Increases Diagnostic Performance in Men with Elevated or Increasing PSA Levels after Previous Negative TRUS BiopsiesEuropean Urology, 2006
- Prostate Saturation Biopsy in the Reevaluation of Microfocal Prostate CancerJournal of Urology, 2006
- Micro-Focal Prostate Cancer: A Comparison of Biopsy and Radical Prostatectomy Specimen FeaturesEuropean Urology, 2005
- MR imaging and MR spectroscopic imaging in the pre-treatment evaluation of prostate cancerThe British Journal of Radiology, 2005
- Extended Peripheral Zone Biopsy Schemes Increase Cancer Detection Rates and Minimize Variance in Prostate Specific Antigen and Age Related Cancer Rates: Results of a Community Multi-Practice StudyJournal of Urology, 2003