Coated Drug Cores in Multiple Unit Preparations Influence of Particle Size

Abstract

The influence of the size of barrier-coated drug cores was investigated using a special experimental design. It was shown that the release rate is directly proportional to the surface area of the coated cores. This means, for example, that four times more coating solution should be needed to maintain the release properties if the particle size is reduced to half of its original value. This large effect of particle size variations is important both concerning product quality and production economy.