Role of the side chain of lanosterol in substrate recognition and catalytic activity of lanosterol 14α-demethylase (cytochrome P-45014DM) of yeast
- 5 February 1991
- journal article
- Published by Elsevier BV in Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
- Vol. 1081 (3), 262-266
- https://doi.org/10.1016/0005-2760(91)90280-u
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- The 3-hydroxy group of lanosterol is essential for orienting the substrate in the substrate site of cytochrome P-45014DM (Lanosterol 14α-demethylase)Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989
- Metabolism of 24,25-dihydrolanosterol analogs by partially purified cytochrome P-45014DM from rat liver microsomes.CHEMICAL & PHARMACEUTICAL BULLETIN, 1989
- A single amino acid substitution converts cytochrome P45014DM to an inactive form, cytochrome P450SG1: Complete primary structures deduced from cloned DNAsBiochemical and Biophysical Research Communications, 1988
- 7-Oxo-24,25-dihydrolanosterol: a novel lanosterol 14α-demethylase (P-45014DM) inhibitor which blocks electron transfer to the oxyferro intermediateBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
- Primary Structure of the P450 Lanosterol Demethylase Gene fromSaccharomyces cerevisiaeDNA, 1987
- Evidence for the presence of cytochrome P-450 functional in lanosterol 14α-demethylation in microsomes of aerobically grown respiring yeastBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1981
- Synthesis of lanosterol analogs with modified side chains.CHEMICAL & PHARMACEUTICAL BULLETIN, 1981
- The 14α—demethylation of lanosterol by a reconstituted cytochrome P-450 system from yeast microsomesBiochemical and Biophysical Research Communications, 1978
- Interaction of lanosterol to cytochrome P-450 purified from yeast microsomes: Evidence for contribution of cytochrome P-450 to lanosterol metabolismBiochemical and Biophysical Research Communications, 1978
- NADPH-cytochrome P-450 reductase of yeast microsomesArchives of Biochemistry and Biophysics, 1978