Comparison of Topical Methyl Aminolevulinate Photodynamic Therapy With Cryotherapy or Fluorouracil for Treatment of Squamous Cell Carcinoma In Situ

Abstract

Nonmelanoma skin cancer, including intraepithelial squamous cell carcinoma (SCC in situ), is the most common cancer in white persons, particularly in northwestern Europe,¹ the United States,² and Australia,³ and the incidence continues torise.⁴ Squamous cell carcinoma in situ is especially common in elderly patients, typically occurring on the lower part of the legs.⁵ The condition is associated with a small risk of progression (about 3%).⁶