Transient Global Amnesia and Neurological Events: The Framingham Heart Study
Open Access
- 1 January 2013
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Neurology
- Vol. 4, 47
- https://doi.org/10.3389/fneur.2013.00047
Abstract
Background/objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurological events. We studied the relation of TGA, vascular risk factors, brain magnetic resonance imaging (MRI) indices of subclinical ischemia and neurological events in a community-based sample. Design/setting: A total of 12 TGA cases were ascertained using standard criteria by experienced neurologists, and matched to 41 stroke- and seizure-free controls. Vascular risk factors, brain MRI findings, and subsequent cerebrovascular or seizure events were compared in cases and controls. Participants: Framingham Heart Study (FHS) original and offspring cohort participants were included. Results: No significant differences between the groups were observed in the prevalence of vascular risk factors, or brain MRI measures. Few incident stroke/transient ischemic attacks (TIA) (one event among the cases and four in controls) or subsequent seizures occurred in either group. Head CT during the acute event (n = 11) and brain MRI (n = 7) were negative for acute abnormalities. Electroencephalograms (EEG) (n = 5) were negative for epileptiform activity. Extracranial vascular studies were negative for significant stenosis in all cases. Conclusion: In our community-based study TGA was not related to traditional vascular risk factors, or cerebrovascular disease. However, our study is limited by small sample size and power, and larger studies are required to exclude an association.This publication has 12 references indexed in Scilit:
- Ischemic bilateral hippocampal dysfunction during transient global amnesiaNeurology, 2007
- Transient Global Amnesia and MigraineHeadache: The Journal of Head and Face Pain, 2005
- Are Triptans Effective and Safe When Taken During the Aura Phase of Migraine?Headache: The Journal of Head and Face Pain, 2005
- Clinical features, risk factors, and prognosis in transient global amnesia: a follow‐up studyEuropean Journal of Neurology, 2005
- Unraveling the enigma of transient global amnesiaAnnals of Neurology, 1998
- Transient Global Amnesia and Transient Ischemic AttackStroke, 1995
- Method for Quantification of Brain, Ventricular, and Subarachnoid CSF Volumes from MR ImagesJournal of Computer Assisted Tomography, 1992
- Differential impairment of semantic and episodic memory in Alzheimer's and Huntington's diseases: a controlled prospective study.Journal of Neurology, Neurosurgery & Psychiatry, 1990
- THE AETIOLOGY OF TRANSIENT GLOBAL AMNESIABrain, 1990
- Transient global amnesia.Stroke, 1983