iAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states
Open Access
- 12 July 2011
- journal article
- Published by Springer Science and Business Media LLC in BMC Systems Biology
- Vol. 5 (1), 110
- https://doi.org/10.1186/1752-0509-5-110
Abstract
The development of high-throughput technologies capable of whole cell measurements of genes, proteins, and metabolites has led to the emergence of systems biology. Integrated analysis of the resulting omic data sets has proved to be hard to achieve. Metabolic network reconstructions enable complex relationships amongst molecular components to be represented formally in a biologically relevant manner while respecting physical constraints. In silico models derived from such reconstructions can then be queried or interrogated through mathematical simulations. Proteomic profiling studies of the mature human erythrocyte have shown more proteins present related to metabolic function than previously thought; however the significance and the causal consequences of these findings have not been explored.Keywords
This publication has 55 references indexed in Scilit:
- Large-scale in silico modeling of metabolic interactions between cell types in the human brainNature Biotechnology, 2010
- What is flux balance analysis?Nature Biotechnology, 2010
- A protocol for generating a high-quality genome-scale metabolic reconstructionNature Protocols, 2010
- Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructionsMolecular Systems Biology, 2010
- HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiologyMolecular Systems Biology, 2010
- Computational reconstruction of tissue‐specific metabolic models: application to human liver metabolismMolecular Systems Biology, 2010
- Applications of genome‐scale metabolic reconstructionsMolecular Systems Biology, 2009
- Predicting metabolic biomarkers of human inborn errors of metabolismMolecular Systems Biology, 2009
- The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coliNature Biotechnology, 2008
- Global reconstruction of the human metabolic network based on genomic and bibliomic dataProceedings of the National Academy of Sciences of the United States of America, 2007