Interleukin-15 Is Critical in the Pathogenesis of Influenza A Virus-Induced Acute Lung Injury
Open Access
- 1 June 2010
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 84 (11), 5574-5582
- https://doi.org/10.1128/jvi.02030-09
Abstract
Highly pathogenic influenza A viruses cause acute severe pneumonia to which the occurrence of “cytokine storm” has been proposed to contribute. Here we show that interleukin-15 (IL-15) knockout (KO) mice exhibited reduced mortality after infection with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) albeit the viral titers of these mice showed no difference from those of control mice. There were significantly fewer antigen-specific CD44 + CD8 + T cells in the lungs of infected IL-15 KO mice, and adoptive transfer of the CD8 + T cells caused reduced survival of IL-15 KO mice following influenza virus infection. Mice deficient in β 2 -microglobulin by gene targeting and those depleted of CD8 + T cells by in vivo administration of anti-CD8 monoclonal antibody displayed a reduced mortality rate after infection. These results indicate that IL-15-dependent CD8 + T cells are at least partly responsible for the pathogenesis of acute pneumonia caused by influenza A virus.Keywords
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