An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls
Open Access
- 4 August 2019
- journal article
- research article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 16 (15), 2786
- https://doi.org/10.3390/ijerph16152786
Abstract
Maternal exposure to polychlorinated biphenyls (PCBs) results in abnormal fetal development, possibly because of epigenetic alterations. However, the association between PCB levels in cord serum with fetal DNA methylation status in cord tissue is unclear. This study aims to identify alterations in DNA methylation in cord tissue potentially associated with PCB levels in cord serum from a birth cohort in Chiba, Japan (male neonates = 32, female neonates = 43). Methylation array analysis identified five sites for female neonates (cg09878117, cg06154002, cg06289566, cg12838902, cg01083397) and one site for male neonates (cg13368805) that demonstrated a change in the methylation degree. This result was validated by pyrosequencing analysis, showing that cg06154002 (tudor domain containing 9: TDRD9) in cord tissue from female neonates is significantly correlated with total PCB levels in cord serum. These results indicate that exposure to PCBs may alter TDRD9 methylation levels, although this hypothesis requires further validation using data obtained from female neonates. However, since the present cohort is small, further studies with larger cohorts are required to obtain more data on the effects of PCB exposure and to identify corresponding biomarkers.This publication has 55 references indexed in Scilit:
- Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesityBMC Medicine, 2013
- Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm EpimutationsPLOS ONE, 2012
- DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVFHuman Reproduction, 2012
- Tobacco-Smoking-Related Differential DNA Methylation: 27K Discovery and ReplicationAmerican Journal of Human Genetics, 2011
- Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat DietPLOS ONE, 2010
- Association of Low-Dose Exposure to Persistent Organic Pollutants with Global DNA Hypomethylation in Healthy KoreansEnvironmental Health Perspectives, 2010
- Hypothesis: a Unifying Mechanism for Nutrition and Chemicals as Lifelong Modulators of DNA HypomethylationEnvironmental Health Perspectives, 2009
- Fetal and Neonatal Exposure to the Endocrine Disruptor Methoxychlor Causes Epigenetic Alterations in Adult Ovarian GenesEndocrinology, 2009
- Global DNA Hypomethylation Is Associated with High Serum-Persistent Organic Pollutants in Greenlandic InuitEnvironmental Health Perspectives, 2008
- DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine statusProceedings of the National Academy of Sciences of the United States of America, 2007