Poly(N‐vinylpyrrolidone)‐Modified Surfaces for Biomedical Applications
- 4 December 2012
- journal article
- review article
- Published by Wiley in Macromolecular Bioscience
- Vol. 13 (2), 147-154
- https://doi.org/10.1002/mabi.201200269
Abstract
Poly(N-vinylpyrrolidone) (PVP), an important water soluble synthetic polymer, has many desirable properties including low toxicity, chemical stability, and good biocompatibility. Since PVP is hemocompatible and physiologically inactive, it has been used as a blood plasma substitute. Surface modification with PVP has been investigated extensively over the past few years as a means of preventing nonspecific protein adsorption. PVP may therefore be seen as a promising antifouling surface modifier comparable to poly(ethylene glycol) (PEG). In this review, various approaches for the design and preparation of PVP-modified surfaces are summarized and potential biomedical applications of these PVP-modified materials are indicated. Finally, some perspectives on future research on PVP for surface modification are discussed.Keywords
This publication has 113 references indexed in Scilit:
- Enhanced Separation Performance of PVDF/PVP-g-MMT Nanocomposite Ultrafiltration Membrane Based on the NVP-Grafted Polymerization Modification of Montmorillonite (MMT)Langmuir, 2012
- Poly(N-vinylpyrrolidone)-modified surfaces repel plasma protein adsorptionChinese Journal of Polymer Science, 2012
- Heparin‐Like Macromolecules for the Modification of Anticoagulant BiomaterialsMacromolecular Bioscience, 2011
- Directly observed Au–S bond breakage due to swelling of the anchored polyelectrolyteChemical Communications, 2010
- Molecular Structure of Physiologically‐Responsive Hydrogels Controls Diffusive BehaviorMacromolecular Bioscience, 2009
- Quartz Crystal Microbalance Study of Protein Adsorption on Chitosan, Chitosan/Poly(vinyl pyrrolidone) Blends and Chitosan-graft-Poly(vinyl pyrrolidone) SurfacesJournal of Bioactive and Compatible Polymers, 2007
- Intrinsic Adhesion Properties of Poly(vinyl pyrrolidone) to Pharmaceutical Materials: Humidity EffectMacromolecular Bioscience, 2005
- Copolymerization of acrylonitrile with N-vinyl-2-pyrrolidone to improve the hemocompatibility of polyacrylonitrilePolymer, 2005
- Surface properties of PEO–silicone composites: reducing protein adsorptionJournal of Biomaterials Science, Polymer Edition, 2005
- Chemical Modification of the Surface of Poly(dimethylsiloxane) by Atom-Transfer Radical Polymerization of AcrylamideLangmuir, 2002