HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis
- 1 March 2007
- journal article
- Published by Springer Science and Business Media LLC in Pediatric Nephrology
- Vol. 22 (3), 376-379
- https://doi.org/10.1007/s00467-006-0324-y
Abstract
To investigate the association between HLA-DRB1* alleles and post-streptococcal acute glomerulonephritis (PSAGN) in Egyptian children, 32 unrelated patients with PSAGN and 380 healthy individuals from the same locality were typed for DRB1* alleles using the polymerase chain-reverse hybridization technique. Patients with PSAGN had significantly increased frequency of both DRB1* 03011 (46.9 vs. 19.2% in controls, P = 0.00025) and DRB1* 1105 (31.1 vs. 15.6% in controls, P = 0.0097) alleles. However, after correction of P values, only the difference for DRB1* 03011 allele remained significant (Pc = 0.025). Their relative risks were significantly high (3.71, confidence interval [CI] = 1.8–7.8, and 3.57, CI = 1.4–8.9 respectively). No significant differences in the frequency of the two alleles were observed among patients with different grades of hypertension or proteinuria. In conclusion, DRB1* 03011, and possibly 1105, alleles confer susceptibility to PSAGN. However, the severity of the disease is not determined by these two alleles.Keywords
This publication has 22 references indexed in Scilit:
- The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and AdolescentsPediatrics, 2004
- Nomenclature for factors of the HLA system, update January/February 1997Human Immunology, 1997
- HLA: what's in a name?Tissue Antigens, 1997
- HLA DP antigens and post‐streptococcal acute glomerulonephriusActa Paediatrica, 1996
- Rapid DNA typing of class II HLA antigens using the polymerase chain reaction and reverse dot blot hybridizationTissue Antigens, 1993
- Superantigenicity of streptococcal M protein.The Journal of Experimental Medicine, 1990
- The Basis for the Immunoregulatory Role of Macrophages and Other Accessory CellsScience, 1987
- Family studies of the HLA system in acute post-streptococcal glomerulonephritisHuman Immunology, 1983
- Circulating Immune Complexes in Patients with Uncomplicated Group A Streptococcal Pharyngitis and Patients with Acute Poststreptococcal GlomerulonephritisAmerican Journal of Nephrology, 1983
- HLA and Acute Poststreptococcal GlomerulonephritisNew England Journal of Medicine, 1979