Age‐related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species
Open Access
- 27 April 2011
- journal article
- review article
- Published by Wiley in Journal Of Physiology-London
- Vol. 589 (9), 2139-2145
- https://doi.org/10.1113/jphysiol.2011.206623
Abstract
Skeletal muscle generates superoxide and nitric oxide at rest and this generation is increased by contractile activity. In young and adult animals and man, an increase in activities of these species and the secondary products derived from them (reactive oxygen species, ROS) stimulate redox‐sensitive signalling pathways to modify the cellular content of cytoprotective regulatory proteins such as the superoxide dismutases, catalase and heat shock proteins that prevent oxidative damage to tissues. The mechanisms underlying these adaptive responses to contraction include activation of redox‐sensitive transcription factors such as nuclear factor κB (NFκB), activator protein‐1 (AP1) and heat shock factor 1 (HSF1). During ageing all tissues, including skeletal muscle, demonstrate an accumulation of oxidative damage that may contribute to loss of tissue homeostasis. The causes of this increased oxidative damage are uncertain, but substantial data now indicate that the ability of skeletal muscle from aged organisms to respond to an increase in ROS generation by increased expression of cytoprotective proteins through activation of redox‐sensitive transcription factors is severely attenuated. This age‐related lack of physiological adaptations to the ROS induced by contractile activity appears to contribute to a loss of ROS homeostasis and increased oxidative damage in skeletal muscle.Keywords
This publication has 48 references indexed in Scilit:
- Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle cross-sectional areaAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010
- Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?Free Radical Biology & Medicine, 2010
- Antioxidants prevent health-promoting effects of physical exercise in humansProceedings of the National Academy of Sciences of the United States of America, 2009
- Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force ProductionPhysiological Reviews, 2008
- The IκB kinases IKKα and IKKβ are necessary and sufficient for skeletal muscle atrophyThe FASEB Journal, 2008
- In Situ Detection and Measurement of Intracellular Reactive Oxygen Species in Single Isolated Mature Skeletal Muscle Fibers by Real Time Fluorescence MicroscopyAntioxidants and Redox Signaling, 2008
- Redox-based regulation of signal transduction: Principles, pitfalls, and promisesFree Radical Biology & Medicine, 2008
- IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesisThe Journal of cell biology, 2008
- Real‐time measurement of nitric oxide in single mature mouse skeletal muscle fibres during contractionsJournal Of Physiology-London, 2007
- Free radicals and tissue damage produced by exerciseBiochemical and Biophysical Research Communications, 1982