Biocellulose Membranes as Supports for Dermal Release of Lidocaine
- 27 October 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 12 (11), 4162-4168
- https://doi.org/10.1021/bm201303r
Abstract
Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTJR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.FCTPOPH/FSESFRH/BPD/63250/200Keywords
This publication has 26 references indexed in Scilit:
- Polymer‐based Biomaterials as Dressings for Chronic Stagnating WoundsMacromolecular Symposia, 2010
- Novel transparent nanocomposite films based on chitosan and bacterial celluloseGreen Chemistry, 2009
- Transparent Nanocomposites Based on Cellulose Produced by Bacteria Offer Potential Innovation in the Electronics Device IndustryAdvanced Materials, 2008
- Pharmaceutical significance of cellulose: A reviewExpress Polymer Letters, 2008
- Main properties and current applications of some polysaccharides as biomaterialsPolymer International, 2007
- Nanocelluloses as Innovative Polymers in Research and ApplicationPublished by Springer Science and Business Media LLC ,2006
- Microbial cellulose—the natural power to heal woundsBiomaterials, 2006
- Optically transparent bionanofiber composites with low sensitivity to refractive index of the polymer matrixApplied Physics Letters, 2005
- Towards electronic paper displays made from microbial celluloseApplied Microbiology and Biotechnology, 2004
- Bacterial synthesized cellulose — artificial blood vessels for microsurgeryProgress in Polymer Science, 2001