Renal Involvement in Patients with Congenital Cyanotic Heart Disease
- 1 December 1991
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 80 (12), 1214-1219
- https://doi.org/10.1111/j.1651-2227.1991.tb11811.x
Abstract
Patients with congenital cyanotic heart disease may develop a glomerulopathy with proteinuria and impaired renal function. In order to investigate this problem we conducted a study on 27 patients with uncorrected cyanotic heart disease who were between 1 day and 25 years old. As a consequence of hypoxaemia haematocrit was elevated to 57%. Proteinuria was above 150 mg/day/1.73 m2 body surface in 12 patients. Only one of 9 children under 10 years of age had pathological proteinuria presenting as isolated albuminuria. Seven out of 10 patients between 11 and 20 years had an elevated proteinuria with a glomerular pattern. Creatinine clearance was normal in these patients. All four patients above 20 years of age had a considerable glomerular proteinuria with a mean excretion of 5.7 g/24 h/1.73 m2 body surface. These patients suffered additionally from chronic cardiac failure and creatinine clearance was below the normal range. There was a clear relationship between pathological proteinuria and age of the patients and thus duration of hypoxaemia. Patients with pathological proteinuria had a significant higher erythrocyte count (7.3 +/- 1.3 vs 5.6 +/- 1.4 10(12)/l p less than 0.01) and a lower mean corpuscular haemoglobin. In summary, children with persistent congenital cyanotic heart disease have substantial risk of developing a glomerulopathy if the cyanosis remains unchanged for more than ten years.Keywords
This publication has 12 references indexed in Scilit:
- Postnatal development of renal function during the first year of lifePediatric Nephrology, 1987
- The Effect of Phlebotomy on Renal Function and Proteinuria in a Patient with Congenital Cyanotic Heart DiseaseNephron, 1983
- A Hypothesis Proposing Increased Blood Viscosity as a Cause of Proteinuria and Increased Vascular PermeabilityNephron, 1982
- Renal Function in Patients with Chronic Hypoxaemia and Cor Pulmonale Following Reversal of PolycythaemiaNephron, 1982
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- RENAL FUNCTION IN FALLOT'S TETRALOGYActa Paediatrica, 1974
- Implications of the glomerular lesions of cyanotic congenital heart diseaseJournal of Chronic Diseases, 1966
- Hyalinization of afferent and efferent glomerular arterioles in cyanotic congenital heart diseaseAmerican Journal Of Medicine, 1966
- The Glomerulus in Cyanotic Congenital Heart Disease and Primary Pulmonary HypertensionNephron, 1964