PD-1 Blockade Expands Intratumoral Memory T Cells

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Abstract
Tumor biopsies from patients treated with antibodies to PD-1 showed that therapy altered tumor composition. T cells, B cells, and myeloid-derived suppressor cells were increased, and patients who responded to anti–PD-1 therapy had increased memory CD8+ T cells.
Funding Information
  • NIH, Cancer Research Institute and Cancer Immunology Dream Team Translational Research (R35 CA197633, P01 CA168585, SU2C-CRI, SU2C-AACR-DT1012)
  • Cancer Phillip A. Sharp Innovation (SU2C-AACR-PS04)
  • Tower Cancer Research Foundation (5T32CA009297-30, 5T32AR058921-05, 5T32CA009120-39)
  • NIH and JCCC, JCCC, the UCLA AIDS Institute, and the David Geffen School of Medicine at UCLA (CA16042, AI 28697)