ALLOXAN DIABETES IN THE DOG1

Abstract

Intraven. administration of alloxan to dogs in a single dose exceeding 100 mg./kg. caused death of the animals within a few hrs. A dose between 75 and 100 mg./kg. produced a diabetic-uremic syndrome of which the animals died within 1 week. A dose of 50-75 mg./kg. produced typical diabetes without renal lesions. These animals could be kept alive for weeks." The main histologic features were a disappearance of the B cells from the islets, profound vacuolation of the pancreatic duct epithelium, and fatty changes of the liver. Doses of 25 mg./kg. were without effect.