Recognition and Stabilization of Peptide α-Helices Using Templatable Nanoparticle Receptors
- 14 August 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (35), 10806-10807
- https://doi.org/10.1021/ja047719h
Abstract
α-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix.This publication has 12 references indexed in Scilit:
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