Low-dose aspirin is a prominent cause of bleeding ulcers in patients who underwent emergency endoscopy
- 13 May 2009
- journal article
- Published by Springer Science and Business Media LLC in The Esophagus
- Vol. 44 (9), 912-918
- https://doi.org/10.1007/s00535-009-0074-2
Abstract
This study aimed to clarify the current situation of bleeding peptic ulcers and examined the temporal changes in the pathogenic mechanisms requiring emergency endoscopy. Study subjects were 285 bleeding peptic ulcer patients who received emergency endoscopy in Saga Medical School Hospital between 2000 and 2007. The ratios of H. pylori infection, NSAID use and low-dose aspirin use were analyzed for differences between the two periods by chi-square test. Logistic regression analysis was used to investigate factors such as patient characteristics that influenced the differences between each period. A total of 221 (77.5%) patients were identified as H. pylori-positive. One hundred (35.1%) patients reported a history of NSAID use within 4 weeks. Among NSAID users, 41 patients received daily low-dose aspirin. One hundred forty-one patients had bleeding ulcers in 2000–2003 and 144 patients in 2004–2007. The odds ratio (OR) between the periods was 0.806 (95% CI, 0.461–1.409) for H. pylori infection and 1.590 (95% CI, 0.973–2.598) for NSAID usage. In contrast, the proportion of patients who took low-dose aspirin was 9.9% in the first period and 18.8% in the second period, and the difference was statistically significant (OR 2.093; 95% CI, 1.047–4.185). Logistic regression analysis revealed that cardiovascular disease and cerebral vascular disease were associated with aspirin use. This study indicates that the causes of bleeding ulcers are changing, and the increasing use of low-dose aspirin might become a major cause of bleeding ulcers.Keywords
This publication has 29 references indexed in Scilit:
- Trends in Management and Outcomes of Acute Nonvariceal Upper Gastrointestinal Bleeding: 1993–2003Clinical Gastroenterology and Hepatology, 2006
- Low-dose aspirin and upper gastrointestinal damage:epidemiology, prevention and treatmentCurrent Medical Research and Opinion, 2006
- Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use in bleeding peptic ulcers in JapanThe Esophagus, 2006
- A clinical study of Japanese patients with ulcer induced by low‐dose aspirin and other non‐steroidal anti‐inflammatory drugsAlimentary Pharmacology & Therapeutics, 2005
- Prevention of the rehaemorrhage of bleeding peptic ulcers: effects of Helicobacter pylori eradication and acid suppressionAlimentary Pharmacology & Therapeutics, 2005
- Concomitant use of buffered and enteric-coated low-dose aspirin products and antisecretory drugsJournal of Clinical Pharmacy & Therapeutics, 2004
- Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patientsBMJ, 2002
- Association between aspirin and upper gastrointestinal complications: Systematic review of epidemiologic studiesBritish Journal of Clinical Pharmacology, 2001
- Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin--analysis of gastrointestinal bleeding during the UK-TIA trial.Gut, 1995
- Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugsThe Lancet, 1994