Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC)
Open Access
- 3 November 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 20 (1), 1-11
- https://doi.org/10.1186/s13058-018-1056-1
Abstract
BackgroundThe association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk.MethodsWe conducted a prospective study of a cohort enriched for familial risk consisting of 16,035 women from 6701 families in the Breast Cancer Family Registry and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer followed for up to 20years (mean 10.5years). There were 896 incident breast cancers (mean age at diagnosis 55.7years). We used Cox regression to model BMI risk associations as a function of menopausal status, age, and underlying familial risk based on pedigree data using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), all measured at baseline.ResultsThe strength and direction of the BMI risk association depended on baseline menopausal status (P<0.001); after adjusting for menopausal status, the association did not depend on age at baseline (P=0.6). In terms of absolute risk, the negative association with BMI for premenopausal women has a much smaller influence than the positive association with BMI for postmenopausal women. Women at higher familial risk have a much larger difference in absolute risk depending on their BMI than women at lower familial risk.ConclusionsThe greater a woman's familial risk, the greater the influence of BMI on her absolute postmenopausal breast cancer risk. Given that age-adjusted BMI is correlated across adulthood, maintaining a healthy weight throughout adult life is particularly important for women with a family history of breast cancer.Funding Information
- National Institutes of Health (1RO1CA159868)
This publication has 55 references indexed in Scilit:
- Hi-Plex for high-throughput mutation screening: application to the breast cancer susceptibility gene PALB2BMC Medical Genomics, 2013
- Body size, modifying factors, and postmenopausal breast cancer risk in a multiethnic population: the San Francisco Bay Area Breast Cancer StudySpringerPlus, 2013
- Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control studyBreast Cancer Research, 2010
- Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutationsBritish Journal of Cancer, 2010
- Body Fatness at Young Ages and Risk of Breast Cancer Throughout LifeAmerican Journal of Epidemiology, 2010
- BRCA1 and BRCA2 mutation carriers in the Breast Cancer Family Registry: an open resource for collaborative researchBreast Cancer Research and Treatment, 2008
- The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensionsBritish Journal of Cancer, 2008
- Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studiesThe Lancet, 2008
- Relative Weight at Age 12 and Risk of Postmenopausal Breast CancerCancer Epidemiology, Biomarkers & Prevention, 2008
- The BOADICEA model of genetic susceptibility to breast and ovarian cancerBritish Journal of Cancer, 2004