The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes
Open Access
- 16 October 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 52 (12), 2590-2593
- https://doi.org/10.1007/s00125-009-1550-1
Abstract
Hyperglycaemia increases oxidative stress and may thereby increase the risk of diabetic complications, including diabetic nephropathy. Cells are protected from oxidative damage by, for example, the manganese superoxide dismutase enzyme (MnSOD), but the functional polymorphism V16A affects the localisation of MnSOD and therefore its ability to scavenge superoxide radicals. In a Danish cohort of type 1 diabetes patients, we sought to confirm previous findings of association between the V allele and the risk of diabetic nephropathy and to investigate the influence of this polymorphism on the development of cardiovascular disease.Keywords
This publication has 9 references indexed in Scilit:
- Manganese superoxide dismutase polymorphism affects the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery diseaseEuropean Heart Journal, 2007
- European rational approach for the genetics of diabetic complications EURAGEDIC: patient populations and strategyNephrology Dialysis Transplantation, 2007
- A Functional Polymorphism in the Manganese Superoxide Dismutase Gene and Diabetic NephropathyDiabetes, 2007
- Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European PopulationsDiabetes, 2006
- The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria.Published by Rockefeller University Press ,2003
- The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patientsJournal of Human Genetics, 2003
- A Nonlinear Effect of Hyperglycemia and Current Cigarette Smoking Are Major Determinants of the Onset of Microalbuminuria in Type 1 DiabetesDiabetes, 2001
- Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageNature, 2000
- Structural Dimorphism in the Mitochondrial Targeting Sequence in the Human Manganese Superoxide Dismutase GeneBiochemical and Biophysical Research Communications, 1996