Dissemination of carbapenemase-producing Enterobacteriaceae in France, 2012
Open Access
- 24 November 2013
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 69 (3), 623-627
- https://doi.org/10.1093/jac/dkt433
Abstract
Carbapenem-resistant Enterobacteriaceae isolates (n = 1485) were received at the French Associated National Reference Center for Antibiotic Resistance in 2012 and were characterized for their mechanism of resistance to carbapenems. Carbapenemase production was detected using the biochemical-based Carba NP test, based on the detection of in vitro hydrolysis of imipenem. All isolates with a positive Carba NP test result were characterized by PCR and sequencing. Carbapenemase production was identified in 23.1% of the isolates. The main carbapenemase type identified was OXA-48 and derivatives (75.5%). An overseas source was clearly demonstrated for only 27.6% of the isolates. OXA-48 and derivatives are now the most prevalent carbapenemases in France, with a possible spread of these producers in the community.Keywords
This publication has 10 references indexed in Scilit:
- Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected?Clinical Microbiology & Infection, 2013
- Strategies for identification of carbapenemase-producing EnterobacteriaceaeJournal of Antimicrobial Chemotherapy, 2012
- Rapid Detection of Carbapenemase-producingEnterobacteriaceaeEmerging Infectious Diseases, 2012
- Link Between Carbapenemase‐ProducingEnterobacteriaCarriage and Cross‐Border Exchanges: Eight‐Year Surveillance in a Large French Multihospitals InstitutionJournal of Travel Medicine, 2012
- Rapid evolution and spread of carbapenemases among Enterobacteriaceae in EuropeClinical Microbiology & Infection, 2012
- OXA-48-like carbapenemases: the phantom menaceJournal of Antimicrobial Chemotherapy, 2012
- Carbapenem resistance in Enterobacteriaceae: here is the storm!Trends in Molecular Medicine, 2012
- The emerging NDM carbapenemasesTrends in Microbiology, 2011
- Combating Antimicrobial Resistance: Policy Recommendations to Save LivesClinical Infectious Diseases, 2011
- The real threat of Klebsiella pneumoniae carbapenemase-producing bacteriaThe Lancet Infectious Diseases, 2009