Obesity and Disease Management: Effects of Weight Loss on Comorbid Conditions
- 1 November 2001
- journal article
- research article
- Published by Wiley in Obesity Research
- Vol. 9 (S11), 326S-334S
- https://doi.org/10.1038/oby.2001.138
Abstract
This review is designed to quantitate the effects of obesity and weight gain on risk for coronary heart disease (CHD) and to review the effects of weight loss on CHD risk factors. After a comprehensive review of the literature related to body weight and weight gain on CHD risk, the relative risks (RRs) were tabulated. Values were averaged and meta-analysis techniques were used to estimate the variance-adjusted RR. Young persons with higher body mass index values have a significantly higher risk for CHD than do slender young people. For every 1% above a desirable body mass index, the risk for CHD increases by 3.3% for women and by 3.6% for men. Every kilogram of weight gain after high school increases risk for CHD by 5.7% for women and 3.1% for men. Weight loss significantly decreases major CHD risk factors. For every kilogram of weight loss the following favorable changes occur: fasting serum cholesterol, -1.0%; low-density lipoprotein cholesterol, -0.7%; triglycerides, -1.9%; high-density lipoprotein cholesterol, +0.2%; systolic blood pressure, -0.5%; diastolic blood pressure, -0.4%; and blood glucose, -0.2 mM. Obesity and/or weight gain are associated with major risk for CHD. Weight loss significantly improves serum lipid parameters, blood pressure, and fasting blood glucose values. Effective treatment approaches are available for most overweight or obese individuals but a major challenge is to enable these individuals to engage in these programs. Professional and consumer education is essential for advancing effective intervention strategies for overweight individuals.Keywords
This publication has 48 references indexed in Scilit:
- Successful Long-Term Maintenance of Substantial Weight Loss: One Program's ExperienceJournal of the American Dietetic Association, 2000
- Body-Mass Index and Mortality in a Prospective Cohort of U.S. AdultsNew England Journal of Medicine, 1999
- C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial DysfunctionArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- Clinical evaluation of a minimal intervention meal replacement regimen for weight reduction.Journal of the American College of Nutrition, 1994
- Food-Containing Hypocaloric Diets Are As Effective As Liquid-Supplement Diets for Obese Individuals With NIDDMDiabetes Care, 1994
- Diet, lipids and cardiovascular disease in women.Journal of the American College of Nutrition, 1993
- Plasma triglyceride and coronary heart disease.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991
- A Prospective Study of Obesity and Risk of Coronary Heart Disease in WomenNew England Journal of Medicine, 1990
- Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with DyslipidemiaNew England Journal of Medicine, 1987
- Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.Circulation, 1983