Neuroblastoma: Molecular Pathogenesis and Therapy
Top Cited Papers
- 14 January 2015
- journal article
- review article
- Published by Annual Reviews in Annual Review of Medicine
- Vol. 66 (1), 49-63
- https://doi.org/10.1146/annurev-med-011514-023121
Abstract
Neuroblastoma is a developmental tumor of young children arising from the embryonic sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death from pediatric cancer for children between the ages of one and five years and accounts for ∼13% of all pediatric cancer mortality. Its clinical impact and unique biology have made this aggressive malignancy the focus of a large concerted translational research effort. New insights into tumor biology are driving the development of new classification schemas. Novel targeted therapeutic approaches include small-molecule inhibitors as well as epigenetic, noncoding-RNA, and cell-based immunologic therapies. In this review, recent insights regarding the pathogenesis and biology of neuroblastoma are placed in context with the current understanding of tumor biology and tumor/host interactions. Systematic classification of patients coupled with therapeutic advances point to a future of improved clinical outcomes for this biologically distinct and highly aggressive pediatric malignancy.Keywords
This publication has 92 references indexed in Scilit:
- Genetic Diversity in Normal Cell Populations is the Earliest Stage of Oncogenesis Leading to Intra-Tumor HeterogeneityFrontiers in Oncology, 2013
- Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG projectBritish Journal of Cancer, 2012
- Induction of the neural crest state: Control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactionsDevelopmental Biology, 2012
- Association of Age at Diagnosis and Genetic Mutations in Patients With NeuroblastomaPublished by American Medical Association (AMA) ,2012
- prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate borderDevelopmental Biology, 2011
- The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in NeuroblastomaMolecular Cell, 2010
- Analysis of early human neural crest developmentDevelopmental Biology, 2010
- miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasisNature, 2010
- Treatment of localised resectable neuroblastoma. Results of the LNESG1 study by the SIOP Europe Neuroblastoma GroupBritish Journal of Cancer, 2008
- Identification of ALK as a major familial neuroblastoma predisposition geneNature, 2008