Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
- 4 July 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 10 (8), 813-815
- https://doi.org/10.1038/nm1078
Abstract
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.Keywords
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