Prospective longitudinal assessment of late anthracycline cardiotoxicity after childhood cancer: the role of diastolic function
Open Access
- 1 October 2004
- Vol. 90 (10), 1214-1216
- https://doi.org/10.1136/hrt.2003.027516
Abstract
It has been suggested that diastolic changes precede systolic dysfunction in various conditions and predict later deterioration. Similarly, LV restriction has been suggested to be a late functional event after anthracycline exposure. Most reports of anthracycline cardiotoxicity are cross-sectional studies of heterogeneous diagnostic groups receiving various anthracycline schedules.5 We obtained prospective longitudinal diastolic data in two well defined cohorts of long term survivors of ALL and Wilms’ tumor (WT) and compared this to systolic function. Both cohorts underwent echocardiographic evaluation in 1991–92 and again in 1995–96.Keywords
This publication has 5 references indexed in Scilit:
- Late anthracycline cardiotoxicity after childhood cancerCancer, 2003
- Low-dose daunorubicin in induction treatment of childhood acute lymphoblastic leukemia: No long-term cardiac damage in a randomized study of the Dutch Childhood Leukemia Study GroupMedical and Pediatric Oncology, 2000
- Left Ventricular Diastolic Filling Patterns Associated with Progressive Anthracycline-Induced Myocardial Damage: A Prospective StudyPediatric Cardiology, 1999
- Anthracycline dose in childhood acute lymphoblastic leukemia: issues of early survival versus late cardiotoxicity.Journal of Clinical Oncology, 1997
- Cardiac function in Wilms' tumor survivors.Journal of Clinical Oncology, 1995