Update on the Role of Substantia Nigra Pars Reticulata in the Regulation of Seizures

Abstract
The substantia nigra pars reticulata (SNR) represents an endogenous seizure suppressing system, which may be targeted to develop treatments for generalized or multifocal epilepsies. This review summarizes the region-, age-, and sex-specific features of the SNR-based seizure-controlling network.