Adriamycin-loaded niosomes: drug entrapment, stability and release
- 1 January 1987
- journal article
- other
- Published by Informa UK Limited in Journal of Microencapsulation
- Vol. 4 (4), 321-328
- https://doi.org/10.3109/02652048709021824
Abstract
The effect of encapsulation of adriamycin into niosomes, and its resultant chemical purity, was studied by means of HPLC and high-speed scanning spectrophotometry (the simultaneous use of which allowed investigation of potential non-fluorescent drug degradation products), and the process shown not to adversely affect the drug. Efficiency of entrapment of aqueous solutions of the drug was apparently dependant on neither vesicle composition nor method of production, and evidence of a degree of surfactant-adriamycin association was provided by the high entrapment values. Light-induced drug degradation was reduced by niosome encapsulation, and efflux of entrapped adriamycin was decreased by inclusion of cholesterol into the vesicles, in a manner similar to that reported for liposome preparations. Thus only chemically pure adriamycin was entrapped in, and released from, niosomes.Keywords
This publication has 12 references indexed in Scilit:
- Non-ionic surfactant vesicles, niosomes, as a delivery system for the anti-leishmanial drug, sodium stibogluconateJournal of Pharmacy and Pharmacology, 1986
- The effect of niosomes and polysorbate 80 on the metabolism and excretion of methotrexate in the mouseJournal of Microencapsulation, 1986
- The preparation and properties of niosomes—non-ionic surfactant vesiclesJournal of Pharmacy and Pharmacology, 1985
- The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in miceJournal of Pharmacy and Pharmacology, 1985
- Determination of adriamycin, adriamycinol and their 7-deoxy aglycones in human serum by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1984
- Dispersions of lamellar phases of non‐ionic lipids in cosmetic productsInternational Journal of Cosmetic Science, 1979
- AN ELECTRON SPIN RESONANCE STUDY ON THE ASSOCIATION OF NITROXIDE SPIN PROBES WITH AGGREGATES OF PEPTIDE-SURFACTANTSChemistry Letters, 1979
- A totally synthetic bilayer membraneJournal of the American Chemical Society, 1977
- The effect of chain length and lipid phase transitions on the selective permeability properties of liposomesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1975
- Structure and Physicochemical Properties of Adriamycin (Doxorubicin)Published by Springer Science and Business Media LLC ,1972