A Double‐Blind, Parallel Comparison of Ketoprofen, Aspirin, and Placebo in Patients With Postpartum Pain
- 12 November 1986
- journal article
- research article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 26 (8), 706-711
- https://doi.org/10.1002/j.1552-4604.1986.tb02977.x
Abstract
Our purpose was to evaluate the analgesic efficacy of single oral doses of ketoprofen 25, 50, and 100 mg compared with aspirin 650 mg and placebo in the relief of moderate to severe postepisiotomy, uterine cramping, or cesarean section pain. One hundred and fifty‐six patients participated in a randomized, double‐blind, stratified, parallel‐group study. They were observed over a six‐hour period by one nurse‐observer. Several of the standard summary measures of analgesia were derived from the interview data, including the sum of pain intensity differences (SPID) and the sum of the hourly relief values (TOTAL). The study showed significant differences between aspirin and placebo for four‐hour SPID and several other parameters and between ketoprofen at all dose levels and placebo for the four‐ and six‐hour SPID and many other parameters. The two higher doses of ketoprofen were significantly more effective than aspirin as assessed by the four‐ and six‐hour SPID, TOTAL, and other summary measures. The low dose of ketoprofen, although not significantly different from aspirin for SPID and TOTAL, showed a significantly faster onset of relief and had a better global rating. This study suggests that 50 mg of ketoprofen may be the clinical dose of choice as an analgesic. There were no adverse effects reported.This publication has 6 references indexed in Scilit:
- A Comparative Oral Analgesic Study of Indoprofen, Aspirin, and Placebo in Postpartum PainThe Journal of Clinical Pharmacology, 1985
- Double‐Blind Parallel Comparison of Single Oral Doses of Ketoprofen, Codeine, and Placebo in Patients with Moderate to Severe Dental PainThe Journal of Clinical Pharmacology, 1984
- A Double‐Blind Parallel Comparison of Ketoprofen, Codeine, and Placebo in Patients with Moderate to Severe Postpartum PainThe Journal of Clinical Pharmacology, 1984
- Analgesic Effect of Graded Doses of Flurbiprofen in Post‐Episiotomy PainPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1983
- Closure of the Newman-Keuls Multiple Comparisons ProcedureJournal of the American Statistical Association, 1981
- A bioassay computer program for analgesic clinical trialsCancer Cell, 1967