Metabolic Studies withTrans-5-Amino-3-[2-(5-Nitro-2-Furyl)Vinyl]-1,2,4-[5-14C]Oxadiazole (SQ 18,506): 1. Reductive Cleavage of the 1, 2, 4-oxadiazole ring
- 1 January 1973
- journal article
- research article
- Published by Informa UK Limited in Xenobiotica
- Vol. 3 (2), 97-102
- https://doi.org/10.3109/00498257309151504
Abstract
1. Reductive cleavage of the oxadiazole ring of trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-[5-14C]oxadiazole (SQ 18,506-14C) has been demonstrated both enzymically and chemically. 2. Oral administration of SQ 18,506-14C to humans and rat resulted in the formation of respiratory 14CO2 and the excretion of 14C-urea in the urine. 3. Formation of 14CO2 was demonstrated in vitro by incubation of SQ 18,506-14C with homogenate of human or mouse liver or with milk xanthine oxidase. 4. 14C-urea was isolated after reduction of SQ 18,506-14C by ferrous hydroxide.Keywords
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