Effects of Potential Agonist-Replacement Therapies for Stimulant Dependence on Inhibitory Control in Cocaine Abusers
- 1 January 2008
- journal article
- clinical trial
- Published by Taylor & Francis Ltd in The American Journal of Drug and Alcohol Abuse
- Vol. 34 (3), 293-305
- https://doi.org/10.1080/00952990802013565
Abstract
Two experiments were conducted to determine whether methylphenidate or modafinil, two potential pharmacotherapies for stimulant dependence, would impair inhibitory behavior in cocaine users. Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions. A cued go–no-go task was used to measure response execution and inhibition. Subjective and cardiovascular measures were collected. Neither methylphenidate nor modafinil impaired inhibitory control, but produced prototypical subject-rated and cardiovascular effects. The results of these studies may have implications for the use of these drugs as agonist-replacement therapies for stimulant dependence.Keywords
This publication has 16 references indexed in Scilit:
- Acute d-amphetamine pretreatment does not alter stimulant self-administration in humansPharmacology Biochemistry and Behavior, 2007
- A Comparison of Aripiprazole, Methylphenidate, and Placebo for Amphetamine DependenceAmerican Journal of Psychiatry, 2007
- Association of Dopamine Agonist Use With Impulse Control Disorders in Parkinson DiseaseArchives of Neurology, 2006
- Non‐medical use of prescription stimulants among US college students: prevalence and correlates from a national surveyAddiction, 2004
- A Double-Blind, Placebo-Controlled Trial of Modafinil for Cocaine DependenceNeuropsychopharmacology, 2004
- Effects of d-amphetamine on behavioral control in stimulant abusers: the role of prepotent response tendenciesDrug and Alcohol Dependence, 2003
- Risperidone Attenuates the Discriminative-Stimulus Effects of d-Amphetamine in HumansThe Journal of pharmacology and experimental therapeutics, 2003
- Clinical Applications of Modafinil in Stimulant Abusers: Low Abuse PotentialThe American Journal on Addictions, 2002
- Amphetamine Prescribing as a Harm Reduction Measure: A Preliminary StudyAddiction Research, 1997
- Reinstatement of cocaine-reinforced responding in the ratPsychopharmacology, 1981