Increased Interleukin‐1 (IL‐1) Production from LPS‐Stimulated Peripheral Blood Monocytes in Children with Febrile Convulsions
- 1 August 1990
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 79 (8-9), 810-816
- https://doi.org/10.1111/j.1651-2227.1990.tb11559.x
Abstract
Peripheral blood mononuclear cells (MNC) from 27 children with a febrile convulsion were tested for production of interleukin-1 (IL-1) in culture. MNC stimulated with lipopolysaccharide (LPS) showed a significantly increased production of IL-1 when compared to MNC from children without convulsions but with bacterial infections (p less than 0.001), viral infections (p less than 0.005) or no infection (p less than 0.005). Children who had experienced a febrile convulsion were retested several months later; this time the IL-1 production from LPS-stimulated MNC was not different from controls. These results demonstrate that MNC at the time of febrile convulsions have increased sensitivity to LPS and possibly to other IL-1 inducers; the resulting enhanced IL-1 response from sensitized MNC may have a role in the pathogenesis of febrile convulsions.Keywords
This publication has 13 references indexed in Scilit:
- Spontaneous and inducible interleukin 1 production from peripheral blood monocytes in bacterial and viral infections in childrenThe Pediatric Infectious Disease Journal, 1987
- Nosology of febrile convulsions.Archives of Disease in Childhood, 1986
- Interleukin 1 and monitoring of acute infectionsThe Pediatric Infectious Disease Journal, 1985
- Stimulation of Production of Interleukin-1 and an Interleukin-1 Inhibitor in Human MonocytesRheumatology, 1985
- Vasopressin: Its role in antipyresis and febrile convulsionBrain Research Bulletin, 1984
- Interleukin-1Clinical Infectious Diseases, 1984
- Suppression of fever after lesions of the anteroventral third ventricle in guinea pigsBrain Research Bulletin, 1983
- Prostaglandin F2α concentrations in the cerebrospinal fluid of children with febrile convulsions, epilepsy and meningitisBrain & Development, 1983
- Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.The Journal of Immunology, 1982
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968