Ovarian Cancer Pathogenesis: A Model in Evolution
Open Access
- 1 January 2010
- journal article
- review article
- Published by Hindawi Limited in Journal of Oncology
- Vol. 2010, 1-13
- https://doi.org/10.1155/2010/932371
Abstract
Ovarian cancer is a deadly disease for which there is no effective means of early detection. Ovarian carcinomas comprise a diverse group of neoplasms, exhibiting a wide range of morphological characteristics, clinical manifestations, genetic alterations, and tumor behaviors. This high degree of heterogeneity presents a major clinical challenge in both diagnosing and treating ovarian cancer. Furthermore, the early events leading to ovarian carcinoma development are poorly understood, thus complicating efforts to develop screening modalities for this disease. Here, we provide an overview of the current models of ovarian cancer pathogenesis, highlighting recent findings implicating the fallopian tube fimbria as a possible site of origin of ovarian carcinomas. The ovarian cancer model will continue to evolve as we learn more about the genetics and etiology of this disease.Keywords
Funding Information
- National Cancer Institute (K08 CA108748, R21 CA12468, P50 CA105009)
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