Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia
- 1 April 2015
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science Translational Medicine
- Vol. 7 (281), 281re2
- https://doi.org/10.1126/scitranslmed.aaa0763
Abstract
The targeted genotyping of single acute myeloid leukemia cells is technically feasible, identifies the zygosities of concurrent mutations, and suggests that sequencing of bulk populations may underestimate clonal complexity.Keywords
Funding Information
- NIH (P01 CA91955, R01 CA149566, R01 CA114563, R01 CA140657)
- American Cancer Society (#117209-RSG-09-163-01-CNE, #117749-PF-09-288-01-CCE)
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