Recurrent spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension: a prospective study
- 1 November 2003
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 99 (5), 840-842
- https://doi.org/10.3171/jns.2003.99.5.0840
Abstract
Intracranial hypotension due to a spontaneous spinal cerebrospinal fluid (CSF) leak is an increasingly recognized cause of postural headaches, but reliable follow-up data are lacking. The authors undertook a study to determine the risk of a recurrent spontaneous spinal CSF leak. The patient population consisted of a consecutive group of 18 patients who had been evaluated for consideration of surgical repair of a spontaneous spinal CSF leak. The mean age of the 15 women and three men was 38 years (range 22-55 years). The mean duration of follow up was 36 months (range 6-132 months). The total follow-up time was 654 months. A recurrent spinal CSF leak was defined on the basis of computerized tomography myelography evidence of a CSF leak in a previously visualized but unaffected spinal location. Five patients (28%) developed a recurrent spinal CSF leak; the mean age of these four women and one man was 36 years. A recurrent CSF leak developed in five (38%) of 13 patients who had undergone surgical CSF leak repair, compared with none (0%) of five patients who had been treated non-surgically (p = 0.249). The recurrent leak occurred between 10 and 77 months after the initial CSF leak, but within 2 or 3 months of successful surgical repair of the leak in all patients. Recurrent spontaneous spinal CSF leaks are not rare, and the recent successful repair of such a leak at another site may be an important risk factor.Keywords
This publication has 14 references indexed in Scilit:
- Orthostatic Headache Syndrome with Csf Leak Secondary To Bony Pathology of the Cervical SpineCephalalgia, 2002
- Spontaneous spinal cerebrospinal fluid leaks and minor skeletal features of Marfan syndrome: a microfibrillopathyJournal of Neurosurgery, 2002
- Spontaneous spinal cerebrospinal fluid leaks and intracranial hypotensionJournal of Neurosurgery, 1996
- Spontaneous intracranial hypotension.Journal of Neurology, Neurosurgery & Psychiatry, 1995
- Spontaneous intracranial hypotensionNeurology, 1992
- Aortic collagenase activity as affected by laparotomy, cecal resection, aortic mobilization, and aortotomy in ratsJournal of Vascular Surgery, 1984
- Laparotomy as a Precipitating Factor in the Rupture of Intra-abdominal AneurysmsArchives of Surgery, 1980
- Primary Intracranial HypotensionHeadache: The Journal of Head and Face Pain, 1970
- Low spinal fluid pressure syndromesNeurology, 1960