Vascular Endothelial Growth Factor Increases Neurogenesis after Traumatic Brain Injury
Open Access
- 13 January 2010
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 30 (5), 1008-1016
- https://doi.org/10.1038/jcbfm.2009.271
Abstract
Activation of endogenous stem cells has been proposed as a novel form of therapy in a variety of neurologic disorders including traumatic brain injury (TBI). Vascular endothelial growth factor (VEGF) is expressed in the brain after TBI and serves as a potent activator of angiogenesis and neurogenesis. In this study, we infused exogenous VEGF into the lateral ventricles of mice for 7 days after TBI using mini-osmotic pumps to evaluate the effects on recovery and functional outcome. The results of our study show that VEGF significantly increases the number of proliferating cells in the subventricular zone and in the perilesion cortex. Fate analysis showed that most newborn cells differentiated into astrocytes and oligodendroglia and only a few cells differentiated into neurons. Functional outcome was significantly better in mice treated with VEGF compared with vehicle-treated animals after TBI. Injury size was significantly smaller at 90 days after TBI in VEGF-treated animals, suggesting additional neuroprotective effects of VEGF. In conclusion, VEGF significantly augments neurogenesis and angiogenesis and reduces lesion volumes after TBI. These changes are associated with significant improvement in recovery rates and functional outcome.Keywords
This publication has 39 references indexed in Scilit:
- Dynamic Changes in the Recovery after Traumatic Brain Injury in Mice: Effect of Injury Severity on T2-Weighted MRI Abnormalities, and Motor and Cognitive FunctionsJournal of Neurotrauma, 2008
- Long-Term Neuroblast Migration Along Blood Vessels in an Area With Transient Angiogenesis and Increased Vascularization After StrokeStroke, 2007
- Akt phosphorylation is required for heat acclimation‐induced neuroprotectionJournal of Neurochemistry, 2007
- Long-Lasting Regeneration After Ischemia in the Cerebral CortexStroke, 2007
- Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signalingJournal of Neurobiology, 2005
- Vascular changes in the subventricular zone after distal cortical lesionsExperimental Neurology, 2005
- New roles for astrocytes: The nightlife of an ‘astrocyte’. La vida loca!Trends in Neurosciences, 2003
- Vascular niche for adult hippocampal neurogenesisJournal of Comparative Neurology, 2000
- Platelet-derived growth factor induces chemotaxis of neuroepithelial stem cellsJournal of Neuroscience Research, 1998
- Blood-Brain Barrier Permeability, Cerebral Edema, and Neurologic Function After Closed Head Injury in RatsAnesthesia & Analgesia, 1993