Lebrikizumab Treatment in Adults with Asthma
Top Cited Papers
Open Access
- 22 September 2011
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 365 (12), 1088-1098
- https://doi.org/10.1056/nejmoa1106469
Abstract
Many patients with asthma have uncontrolled disease despite treatment with inhaled glucocorticoids. One potential cause of the variability in response to treatment is heterogeneity in the role of interleukin-13 expression in the clinical asthma phenotype. We hypothesized that anti–interleukin-13 therapy would benefit patients with asthma who had a pretreatment profile consistent with interleukin-13 activity.Keywords
This publication has 27 references indexed in Scilit:
- Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research ProgramAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Subclinical phenotypes of asthmaCurrent Opinion in Allergy and Clinical Immunology, 2010
- Inflammatory phenotypes in adult asthma: clinical applicationsThe Clinical Respiratory Journal, 2009
- Eosinophilic and Neutrophilic Inflammation in Asthma: Insights from Clinical StudiesProceedings of the American Thoracic Society, 2009
- Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous diseaseThe Lancet, 2008
- Cluster Analysis and Clinical Asthma PhenotypesAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Asthma: defining of the persistent adult phenotypesThe Lancet, 2006
- Can Guideline-defined Asthma Control Be Achieved?American Journal of Respiratory and Critical Care Medicine, 2004
- Clinical phenotypes of asthmaCurrent Opinion in Pulmonary Medicine, 2004
- IL-13 receptors and signaling pathways: An evolving webJournal of Allergy and Clinical Immunology, 2003