Targeting RANKL in breast cancer: bone metastasis and beyond
- 1 February 2013
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Anticancer Therapy
- Vol. 13 (2), 195-201
- https://doi.org/10.1586/era.12.177
Abstract
In breast cancer, RANK ligand (RANKL) appears to play an important role in the process of chemotaxis between circulating tumor cells and the bone microenvironment, which enables RANK-expressing breast cancer cells to migrate into the bone. Mounting clinical evidence has further demonstrated that the anti-RANKL monoclonal antibody; denosumab is the most effective approach in the prevention of skeletal-related events. On the other hand, inhibiting RANKL in preclinical models, not only reduced breast cancer formation but also decreased the development of lung metastases, suggesting RANKL as a novel target for breast cancer chemoprevention. In addition, recent data have pointed to a potential role of RANKL in the biology of breast cancer arising at a young age. Hence, RANKL emerges as a key molecule, not only in the field of breast cancer bone metastasis but also in the biology of breast cancer as a whole.info:eu-repo/semantics/publisheKeywords
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