Androgen Receptor Coregulators in Prostate Cancer

Abstract

Androgens play essential roles in male sexual differentiation, sexual maturation, and the maintenance of spermatogenesis (1 , 2) . In addition to such vital roles in reproductive organ development, androgens also mediate physiological responses in a wide range of other tissues and organs including the skin, skeletal muscle, cardiac muscle, liver, kidney, central nervous system, and the hematopoietic system (3) .