Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents
- 1 January 1992
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 355 (6355), 50-55
- https://doi.org/10.1038/355050a0
Abstract
Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.Keywords
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