Clustered arrangement of immunoglobulin λ constant region genes in man
- 1 December 1981
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 294 (5841), 536-540
- https://doi.org/10.1038/294536a0
Abstract
The immunoglobulin lambda light chain locus of man contains six lambda-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. THe sequences of three of these genes correspond to three known non-allelic lambda chain isotypes: Mcg, Ke-Oz- and Ke-Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, lambda-like sequences have also been cloned, suggesting that the lambda genes form an unexpectedly large family within the human genome.Keywords
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