Efavirenz Intoxication Due to Slow Hepatic Metabolism
Open Access
- 1 February 2005
- journal article
- case report
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 40 (3), e22-e23
- https://doi.org/10.1086/427031
Abstract
We describe a human immunodeficiency virus–positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.Keywords
This publication has 9 references indexed in Scilit:
- Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimensBiochemical and Biophysical Research Communications, 2004
- Efavirenz Plasma Concentrations in HIV-Infected PatientsTherapeutic Drug Monitoring, 2004
- A manic episode associated with efavirenz therapy for HIV infectionAIDS, 2003
- The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic ActivityJournal of Pharmacology and Experimental Therapeutics, 2003
- Efavirenz-induced catatoniaAIDS, 2002
- Central Nervous System Adverse Effects with Efavirenz: Case Report and ReviewPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2002
- Management of sudden psychiatric disorders related to efavirenzAIDS, 2001
- Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patientsAIDS, 2001
- EfavirenzDrugs, 1998