FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas
- 21 April 1995
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 268 (5209), 411-415
- https://doi.org/10.1126/science.7536343
Abstract
Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis. A protein tyrosine phosphatase, FAP-1, capable of interacting with the cytosolic domain of Fas, was identified. The carboxyl terminal 15 amino acids of Fas are necessary and sufficient for interaction with FAP-1. FAP-1 expression is highest in tissues and cell lines that are relatively resistant to Fas-mediated cytotoxicity. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line. These findings are consistent with an inhibitory effect of FAP-1 on Fas signal transduction.Keywords
This publication has 20 references indexed in Scilit:
- The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene clusterImmunity, 1994
- Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas MoleculeScience, 1994
- Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligandCell, 1994
- The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and deathCell, 1994
- Molecular cloning of a novel protein‐tyrosine phosphatase containing a membrane‐binding domain and GLGF repeatsFEBS Letters, 1994
- Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor familyCell, 1993
- Establishment of apoptosis‐inducing monoclonal antibody 2D1 and 2D1‐resistant variants of human T cell linesEuropean Journal of Immunology, 1993
- APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expressionEuropean Journal of Immunology, 1993
- Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisNature, 1992
- The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosisCell, 1991