Vagal Withdrawal and Susceptibility to Cardiac Arrhythmias in Rats with High Trait Aggressiveness
Open Access
- 4 July 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (7), e68316
- https://doi.org/10.1371/journal.pone.0068316
Abstract
Personality characteristics, e.g. aggressiveness, have long been associated with an increased risk of cardiac disease. However, the underlying mechanisms remain unclear. In this study we used a rodent model for characterizing cardiac autonomic modulation in rats that differ widely in their level of aggressive behavior. To reach this goal, high-aggressive (HA, n = 10) and non-aggressive (NA, n = 10) rats were selected from a population (n = 121) of adult male Wild-type Groningen rats on the basis of their latency time to attack (ALT, s) a male intruder in a resident-intruder test lasting 600 s. In order to obtain information on their cardiac autonomic modulation, ECG recordings were subsequently obtained via radiotelemetry at rest, during stressful stimuli and under autonomic pharmacological manipulations, and analyzed by means of time- and frequency-domain indexes of heart rate variability. During resting conditions, HA rats (ALT600 s). Exposure to stressful stimuli (i.e. restraint and psychosocial stress) provoked similar tachycardic responses between the two groups. However, under stress conditions HA rats displayed a reduced vagal antagonism and an increased incidence of tachyarrhythmias compared to NA rats. In addition, beta-adrenergic pharmacological stimulation induced a much larger incidence of ventricular tachyarrhythmias in HA rats compared to NA counterparts. These findings are consistent with the view that high levels of aggressive behavior in rats are associated to signs of cardiac autonomic impairment and increased arrhythmogenic susceptibility that may predict vulnerability to cardiac morbidity and mortality.This publication has 46 references indexed in Scilit:
- Nitric oxide synthesis blockade reduced the baroreflex sensitivity in trained ratsAutonomic Neuroscience, 2009
- Individual differences in cardiovascular response to social challengeNeuroscience & Biobehavioral Reviews, 2005
- Coping styles in animals: current status in behavior and stress-physiologyNeuroscience & Biobehavioral Reviews, 1999
- Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarctionThe Lancet, 1998
- Heart rate variability: Origins, methods, and interpretive caveatsPsychophysiology, 1997
- Cardiac Autonomic Function and Incident Coronary Heart Disease: A Population-based Case-Cohort Study: The ARIC StudyAmerican Journal of Epidemiology, 1997
- Electrode Positioning for Reliable Telemetry ECG Recordings During Social Stress in Unrestrained RatsPhysiology & Behavior, 1996
- Cardiac vagal tone: A physiological index of stressNeuroscience & Biobehavioral Reviews, 1995
- Heart rate variability: A measure of cardiac autonomic toneAmerican Heart Journal, 1994
- Type A Behavior and Survival after Acute Myocardial InfarctionThe New England Journal of Medicine, 1985