Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia
- 12 February 1993
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 259 (5097), 968-971
- https://doi.org/10.1126/science.8438156
Abstract
One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1, a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromeric to IL-3 and GM-CSF. Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.Keywords
This publication has 31 references indexed in Scilit:
- Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2Science, 1993
- Identification and characterization of the familial adenomatous polyposis coli geneCell, 1991
- Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal CancersScience, 1991
- An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumorCell, 1990
- Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.Proceedings of the National Academy of Sciences of the United States of America, 1989
- Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genesCell, 1989
- The gene for human complement component C9 mapped to chromosome 5 by polymerase chain reactionGenomics, 1989
- Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1Nature, 1989
- The Human Gene Encoding GM-CSF Is at 5q21-q32, the Chromosome Region Deleted in the 5q - AnomalyScience, 1985
- Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.Proceedings of the National Academy of Sciences of the United States of America, 1984