Two‐Event Model for Carcinogenesis: Biological, Mathematical, and Statistical Considerations
- 1 June 1990
- journal article
- review article
- Published by Wiley in Risk Analysis
- Vol. 10 (2), 323-341
- https://doi.org/10.1111/j.1539-6924.1990.tb01053.x
Abstract
A two‐mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time‐dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.Keywords
This publication has 46 references indexed in Scilit:
- A model for embryonal rhabdomyosarcoma tumorigenesis which involves genome imprintingCell Differentiation and Development, 1989
- Two‐stage models of tumor incidence for historical control animals in the national toxicology program's carcinogenicity experimentsJournal of Toxicology and Environmental Health, 1989
- Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11Nature, 1988
- Pharmacokinetics, biochemical mechanism and mutation accumulation: a comprehensive model of chemical carcinogenesisToxicology Letters, 1988
- A Cellular Dynamics Model of Experimental Bladder Cancer: Analysis of the Effect of Sodium Saccharin in the RatRisk Analysis, 1988
- A stochastic Gompertz birth-death processStatistics & Probability Letters, 1986
- Tests for Differences in Tumor Incidence Based on Animal Carcinogenesis ExperimentsJournal of the American Statistical Association, 1984
- Promoting effect of 4-dimethylaminoazobenzene on enzyme altered foci induced in rat liver by N-nitrosodiethanolamineCarcinogenesis: Integrative Cancer Research, 1984
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences of the United States of America, 1971