Gait Variability Is Associated with Subclinical Brain Vascular Abnormalities in High-Functioning Older Adults
- 27 November 2007
- journal article
- research article
- Published by S. Karger AG in Neuroepidemiology
- Vol. 29 (3-4), 193-200
- https://doi.org/10.1159/000111582
Abstract
Background: Gait variability is an index of how much gait parameters, such as step length, change from one step to the next. Gait variability increases with age and in individuals affected by cortical and subcortical neurodegenerative conditions, and it is associated with falls and incident mobility disability. The brain anatomical correlates of gait variability have not been studied in high-functioning community-dwelling older adults. Methods: Gait variability and brain MRIs were assessed in a cohort of 331 men and women (mean age = 78.3 years) free from stroke, dementia or Parkinson’s disease. Gait variability was computed for spatial parameters (step length and step width) and for temporal parameters (stance time). Subclinical brain vascular abnormalities were measured on brain MRIs as infarcts and white matter hyperintensities. Results: Greater variability of step length was associated with greater prevalence of infarcts, including infarcts in the basal ganglia, and with greater white matter hyperintensities severity, independent of age, gender, cognitive function and cardiovascular disease. Weaker associations were found between the other variability measures and the MRI measures. Conclusion: In this group of older adults free from neurodegenerative diseases, a greater variability of step length was associated with greater burden of subclinical brain vascular abnormalities as defined by MRI.Keywords
This publication has 38 references indexed in Scilit:
- Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's diseaseEuropean Journal of Neuroscience, 2006
- Gait Variability in Community Dwelling Adults With Alzheimer DiseaseAlzheimer Disease & Associated Disorders, 2006
- Subclinical Brain Magnetic Resonance Imaging Abnormalities Predict Physical Functional Decline in High‐Functioning Older AdultsJournal of the American Geriatrics Society, 2005
- White matter hyperintensities are related to physical disability and poor motor functionJournal of Neurology, Neurosurgery & Psychiatry, 2005
- Incidence, Manifestations, and Predictors of Worsening White Matter on Serial Cranial Magnetic Resonance Imaging in the ElderlyStroke, 2005
- Gait Variability in Community‐Dwelling Older AdultsJournal of the American Geriatrics Society, 2001
- Gait Variability in Community-Dwelling Older AdultsJournal of the American Geriatrics Society, 2001
- The joint effect of apolipoprotein E epsilon4 and MRI findings onlower- extremity function and decline in cognitive functionThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2000
- Gait variability and basal ganglia disorders: Stride‐to‐stride variations of gait cycle timing in parkinson's disease and Huntington's diseaseMovement Disorders, 1998
- Clinical Correlates of White Matter Findings on Cranial Magnetic Resonance Imaging of 3301 Elderly PeopleStroke, 1996