Mesna, doxorubicin, ifosfamide, and dacarbazine (MAID) chemotherapy for gynecological sarcomas
- 1 November 2002
- journal article
- Published by BMJ in International Journal of Gynecologic Cancer
- Vol. 12 (6), 745-748
- https://doi.org/10.1046/j.1525-1438.2002.01139.x
Abstract
This report summarizes our experience with the combination of mesna, doxorubicin, ifosfamide, and dacarbazine (MAID) for patients with gynecological sarcomas. We reviewed the records of all patients who had received the MAID regimen for a gynecological sarcoma between 1993 and 2000. The MAID regimen was administered intravenously every 4 weeks in the hospital as follows: (1) mesna 1500 mg/m2/day x 4 days; (2) doxorubicin 15 mg/m2/day x 3 days; (3) ifosfamide 1500 mg/m2/day x 3 days; (4) dacarbazine 250 mg/m2/day x 3 days. The results of treatment with MAID were disappointing. Overall, the response rate was 9% with one complete response and one partial response (both in patients with uterine leiomyosarcoma). We did not observe any responses among the patients with carcinosarcomas of either ovarian or uterine origin. The median progression-free interval and survival were 11 months and 29 months, respectively. This regimen was associated with substantial toxicity (including a death from neutropenic sepsis) as well as high cost and inconvenience due to the requirement for inpatient administration. Although our study contains a limited number of patients with a variety of gynecological sarcomas, our review has led us to discontinue using MAID. It remains to be established if any combination chemotherapy regimen is better than single agent treatment.Keywords
This publication has 4 references indexed in Scilit:
- Mesna, Doxorubicin, Ifosfamide, and Dacarbazine Chemotherapy for Ovarian Mixed Müllerian Sarcoma: Report of Four CasesGynecologic Oncology, 1995
- Phase II trial of ifosfamide and mesna in mixed mesodermal tumors of the uterus (A Gynecologic Oncology Group Study)American Journal of Obstetrics and Gynecology, 1989
- Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicinVersus doxorubicin and cyclophosphamide (a phase III trial of the gynecologic oncology group)Cancer, 1985
- A randomized study of adriamycin with and without dimethyl triazenoimidazole carboxamide in advanced uterine sarcomasCancer, 1983