Disability and Survival of Multiple Sclerosis in Saskatoon, Saskatchewan
Open Access
- 1 January 2010
- journal article
- research article
- Published by Cambridge University Press (CUP) in Canadian Journal of Neurological Sciences
- Vol. 37 (1), 28-35
- https://doi.org/10.1017/s0317167100009616
Abstract
Background: A population-based prevalent group of 150 clinical definite patients ascertained on 1 January 1977, in Saskatoon, Saskatchewan, was followed for 30 years. Objectives: To outline the clinical characteristics, determine the levels of disability at 15, 25, 35, 40, and 45 years after onset, to estimate the survival after onset and life expectancy. Methods: Clinical records were maintained, and the cohort reviewed each decade for 30 years. The disability levels according to the Kurtzke Extended Disability Status Scale were recorded and survival times were estimated. SPSS and Kaplan-Meier methods were used for analysis. Results: On prevalence day, 1 January 1977, there were 48(32%) men and 102(68%) women, with an average age of onset of 32.2±10 years and 28.4±8.6 years. The average duration of disease was 15.7 years. On 1 January 2007, 39(26%) patients were living, 105(70%) deceased, and 6(4%) were missing The disability levels recorded in 1977 and 2007, at 15 and 45 years after onset, were mild (EDSS≤2.5), 33.3% and 8.0%; moderate (EDSS3-5.5), 17.3% and 2.7%; severe (EDSS6-7.5), 6.6% and 4.7%; maximum (EDSS8-9.5), 22.7% and 10.7%. The median survival time after onset was 33 (95% CI: 27.3-38.6) years for men and 38 (95% CI: 34.1-41.9) years for women. The median duration of life was 68.9 years for men and 69.5 years for women, and a decreased life expectancy of 7.7 and 12.8 years. Conclusions: Multiple sclerosis is a progressive neurological disorder and long-term survival is associated with moderate to severe disability and decreased life expectancy.Keywords
This publication has 24 references indexed in Scilit:
- Does benign multiple sclerosis today imply benign multiple sclerosis tomorrow?Neurology, 2007
- Longitudinal follow-up of “benign” multiple sclerosis at 20 yearsNeurology, 2007
- Relapses and Progression of Disability in Multiple SclerosisNew England Journal of Medicine, 2000
- Defining the clinical course of multiple sclerosisNeurology, 1996
- Life expectancy in patients attending multiple sclerosis clinicsNeurology, 1992
- A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, MinnesotaNeurology, 1990
- The Natural History of Multiple SclerosisCanadian Journal of Neurological Sciences, 1987
- COURSE AND PROGNOSIS OF MULTIPLE SCLEROSIS ASSESSED BY THE COMPUTERIZED DATA PROCESSING OF 349 PATIENTSBrain, 1980
- PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSISAnnals of the New York Academy of Sciences, 1965
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958