Correlates of Low Testosterone and Symptomatic Androgen Deficiency in a Population-Based Sample
- 1 October 2008
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 93 (10), 3870-3877
- https://doi.org/10.1210/jc.2008-0021
Abstract
Context: Risk factors for low testosterone and symptomatic androgen deficiency (AD) may be modifiable. Objective: Our objective was to examine demographic, anthropometric, and medical correlates of low testosterone and symptomatic AD. Design: Data were used from the Boston Area Community Health Survey, an epidemiological study conducted from 2002–2005. Setting: Data were obtained from a community-based random sample of racially and ethnically diverse men. Patients or other Participants: Data were available for 1822 men. Main Outcome Measures: Multivariate logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations of covariates with 1) low testosterone and 2) symptomatic AD. The operational definition of low testosterone was serum total testosterone less than 300 ng/dl and free testosterone less than 5 ng/dl; symptomatic AD was defined as the additional presence of symptoms: any of low libido, erectile dysfunction, or osteoporosis or two or more of sleep disturbance, depressed mood, lethargy, or diminished physical performance. Results: Factors associated with low testosterone included age (OR = 1.36; 95% CI= 1.11–1.66, per decade), low per-capita income ($6000 or less per household member vs. more than $30,000; OR = 2.86; 95% CI = 1.39–5.87), and waist circumference (per 10-cm increase; OR = 1.75; 95% CI = 1.45–2.12). Only age (OR = 1.36; 95% CI = 1.04–1.77), waist circumference (OR = 1.88; 95% CI = 1.44–2.47), and health status (OR = 0.21; 95% CI = 0.05–0.92, excellent vs. fair/poor) were associated with our construct of symptomatic AD. Of all variables, waist circumference was the most important contributor in both models. Conclusions: Waist circumference is a potentially modifiable risk factor for low testosterone and symptomatic AD. Manifestation of symptoms may be a consequence of generally poor health status.Keywords
This publication has 34 references indexed in Scilit:
- Prevalence of hypogonadism in males aged at least 45 years: the HIM studyPublished by Hindawi Limited ,2008
- Annual report to the nation on the status of cancer, 1975–2004, featuring cancer in American Indians and Alaska NativesCancer, 2007
- Male menopause-time for a decent burial?Menopause, 2007
- Measuring the Urologic Iceberg: Design and Implementation of the Boston Area Community Health (BACH) SurveyEuropean Urology, 2007
- Testosterone in older men after the Institute of Medicine Report: where do we go from here?Climacteric, 2005
- Low serum testosterone level as a predictor of increased visceral fat in Japanese-American menInternational Journal of Obesity, 2000
- The hypogonadal–obesity cycle: role of aromatase in modulating the testosterone–estradiol shunt – a major factor in the genesis of morbid obesityMedical Hypotheses, 1999
- Marriage, Divorce, and Male TestosteroneSocial Forces, 1998
- A 12-Item Short-Form Health SurveyMedical Care, 1996
- Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperatureJournal of Steroid Biochemistry, 1982