A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs
Open Access
- 3 March 2020
- journal article
- research article
- Published by MDPI AG in Journal of Personalized Medicine
- Vol. 10 (1), 16
- https://doi.org/10.3390/jpm10010016
Abstract
Developing a high-efficiency manufacturing system for personalized medicine plays an important role in increasing the feasibility of personalized medication. The purpose of this study is to investigate the feasibility of a new extrusion-based fabrication process for personalized drugs with a faster production rate. This process uses two syringe pumps with a coaxial needle as an extruder, which extrudes two materials with varying ratios into a capsule. The mixture of hydrogel, polyethylene glycol (PEG), hydroxypropyl methylcellulose, poly acrylic acid and the simulated active pharmaceutical ingredient, Aspirin, was used. To validate the method, samples with different ratios of immediate release (IR) and sustained release (SR) mixtures were fabricated. The results of a dissolution test show that it is feasible to control the release profile by changing the IR and SR ratio using this fabrication setup. The fabrication time for each capsule is about 20 seconds, which is significantly faster than the current 3D printing methods. In conclusion, the proposed fabrication method shows a clear potential to step toward the feasibility of personalized medication.Funding Information
- Congressionally Directed Medical Research Programs (W81XWH-18-1-0137)
This publication has 44 references indexed in Scilit:
- Personalized oncology: Recent advances and future challengesMetabolism, 2013
- Inkjet printing of drug substances and use of porous substrates‐towards individualized dosingJournal of Pharmaceutical Sciences, 2011
- Pharmacogenetics, Pharmacogenomics, and Individualized MedicinePharmacological Reviews, 2011
- Oral drug delivery in personalized medicine: Unmet needs and novel approachesInternational Journal of Pharmaceutics, 2011
- Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic StudiesPLOS ONE, 2009
- Evaluation of novel one-step dry-coated tablets as a platform for delayed-release tabletsJournal of Controlled Release, 2004
- Personalized medicine: revolutionizing drug discovery and patient careTrends in Biotechnology, 2001
- Experiments with AspirinJournal of Chemical Education, 2000
- Ways to minimize adverse drug reactionsPostgraduate Medicine, 1999
- Effect of drug release rate on bioavailability of different aspirin tabletsInternational Journal of Pharmaceutics, 1996