The effect of a meal of meat on glomerular filtration rate in dogs at normal urine flows.

Abstract

The exogenous creatinine clearance of conscious dogs was measured by a method in which no loading doses of water or saline were given. The urine volume was thus in the normal range, 0.1-0.3 ml/min. Under these conditions, the exogenous creatinine clearance of 14 dogs, measured 17 h after a meal, was 2.74 ml/min kg-1 .+-. 0.54 (SD). This is about 40% lower than values usually regarded as normal. A meal of meat, 10 g/kg, increased exogenous creatinine clearance by 12-17 ml/min above the values of 30-50 ml/min found in control experiments, an increase of approximately 40%. Glycine (10 mmol) by stomach tube caused increase in creatinine clearance of similar magnitude to that produced by meat. Creatine (50-150 mmol) had no effect. The observed increase in exogenous creatinine clearance probably reflects an increase in glomerular filtration rate. Since this occurs with small doses of meat, increase in glomerular filtration may be important in normal renal function of dogs.